Applying solitary-molecule optical and AFM imaging and power-spectroscopy approaches, we find to unravel the mechanistic facets of the structure and dynamics of chromosomes. Our research pursuits involve:
Our team reports bacterial cell division and it is aiming to represent a ‘base up biology’ in synthetic cells that can autonomously divide. Our most important fascination lies in cell division, chromatin structure, and spatial Command.
[Laughs] ‘It was certainly a fantastic danger! At the time, I was well knowledgeable that it could go wrong Which I could come to be significantly less profitable, but I just overlooked that. Curiosity has often been my strongest driving force. And luckily everything worked out.’
Considering that 2000, Dekker has shifted the main target of his do the job in the direction of biophysics the place he experiments the Qualities of solitary biomolecules and cells utilizing the applications of nanotechnology. This change of discipline was pushed by his fascination with the exceptional operating of Organic molecular buildings, as well as from the extended-expression standpoint that many fascinating discoveries could be predicted With this industry.[five] Current lines of study in his biophysics group are inside the regions of:[six]
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Immediate immobilization of native yeast iso-one cytochrome c on bare gold: quickly electron relay to redox enzymes and zeptomole protein-movie voltammetry
You're a Christian. If you can make this kind of synthetic mobile, would you be one particular step nearer to God, or would the function of God have diminished to some degree once again?
Stream-pushed rotary motors such as windmills and water wheels generate useful procedures in human Modern society. Although examples of these kinds of rotary motors also aspect prominently in mobile biology, their artificial construction in the nanoscale has remained demanding. Below we reveal flow-driven rotary motion of a self-organized DNA nanostructure which is docked onto a nanopore in a thin reliable-condition membrane. An elastic DNA bundle self-assembles right into a chiral conformation on phoretic docking onto the reliable-condition nanopore, and subsequently displays a sustained unidirectional rotary motion of up to 20 rev s−1.
Let's say, as opposed to using typical best-down silicon electronics, transistors can be created from the bottom up working with single organic and natural molecules because the switching features? This idea, which turned the basis of nowadays’s field of molecular electronics, initially emerged within the seventies.
There was one issue however — we didn't observe any measurable electrical conduction from The only polymer molecules. We concluded that at The only-molecule stage, conducting polymers ended up essentially not these types of great conductors, which was fairly disappointing. We So broadened our view to test to find more promising molecules.
FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial cell division
Later on we spoke again briefly since Dekker felt that our dialogue of his religion quickly became purely philosophical, whereas Furthermore, it concretely allows him in his work.
Developments in nanotechnology within the 1990s produced creating electronic gadgets from single molecules a chance. Cees Dekker recounts cees dekker how his group produced a space-temperature transistor depending on just one carbon nanotube.
Supercoiling-dependent DNA binding: quantitative modeling and purposes to bulk and solitary-molecule experiments